Bredesen-Protocol Strategies to improve brain health and reverse cognitive decline

At proactive wellness, we believe that there is no more important component of your overall health than brain health.  Yet, before much of the emerging research that is being presented today, not much has been known about how to promote brain health and in particular how to lower risk for dementia/alzheimer’s and how to stabilize it for patients that already have early signs and symptoms.

Keep reading to learn more about our exciting new Brain Health Optimization Program (BHOP), but before we go there, let’s understand a little background and relevant history.

For perspective, according to the CDC, Alzheimer’s disease (AD) is present in 50% of patients in nursing homes, causes more than 110,000 deaths in the US per year and was the 6th leading cause of death overall based on 2015 data. AD affects over 5 million people in the US alone.  Some recent data suggests that the problem is getting worse based on early data from 2016 and 2017.

If we look beyond the United States, dementia is fast becoming one of the world’s most burdensome illnesses. According to the World Health Organization (WHO), there are currently around 47 million people across the globe living with dementia, and this number is expected to reach 75 million by 2030, and 132 million by 2050.  AD is the most common form of dementia, accounting for around 60 to 80 percent of all cases.

Alzheimers Disease Symptoms

Alzheimer’s disease SymptomsNormal Aging
Memory loss that disrupts daily life, especially forgetting newly learned informationForgetting newly learned information such as appointments or names but being able to recall them later
Having difficulty solving everyday problems such as paying billsMaking occasional errors but none that are significant or out of the ordinary
Struggling to complete familiar tasks such as driving home or to workNeeding help setting up new equipment or electronics
Losing track of dates, seasons, or timeTemporarily forgetting the day but having the ability to recall it laterTingling
Difficulty judging distance, spatial relationships, and contrastWorsening vision caused by cataracts
Trouble recalling words for things, following conversations, and speakingShortness of breath
Misplacing items and not being able to retrace stepsUnusual pain
Poor judgement or decision-making; inability to multitaskConfusion
Social withdrawalDifficulty regulating body temperature
Changes in personality and moodBecoming irritated when things are not done a particular and preferred way.

PATIENT RESPONSE

Hi Lynese — Great news – seems a fibroid has disappeared! The ultrasound revealed only one fibroid this time, and it is just a little teensy bit smaller than before. So it hasn’t gotten any bigger at all. And the other fibroid didn’t show up on the ultrasound. smile

Thank goodness I did not get that hysterectomy, huh? and thank goodness I came to you to start the bio-identical hormone therapy. I believe that the progesterone is working. And I’m so glad I’m not on the birth control pills anymore. BTW, haven’t had a period since September, and haven’t had any hot flashes either! Life is good.

AK - Germantown, MD

Hi – hope you are doing well. Are you ready for Thanksgiving? I’m getting there. I wanted to let you know I hit the 30 lb loss today!!! Yeah! So excited! Clothes that didn’t fit are fitting. Clothes I used to wear are too big. Feeling great! A little nervous about tomorrow’s feeding frenzy- but hoping to not overindulge too bad.

LJ - Arlington, VA

My update. I feel pretty good!!! My bleeding is under control and I am now regular for the most part. Sometimes I will have a strange menstral bleed (long and slow), but I will take it compared to my old “normal”. I still love the progesterone and testosterone I am on. They leave me with no side effects.

I was very happy at my recent (Feb 6th) annual doc appt (physical). After the standard blood draw work up, my numbers were:
Vitamin D= 66.9 (down a bit from your work up which was 77, but still good)
Cholesterol=123 (down from 150 in Sept 2011)
Triglycerides=91 (down from 129 in Sept 2011)

So… I am the new spokesperson for HCG! I love that stuff!! smile The second round for me was amazing. I was very disciplined and determined and after about the 3rd day, it become very easy for me. I was able to drop 14lbs in an 18 day cycle!!!! AND….I am keeping that off with very little effort! OMG I couldn’t be happier! I am in the body that I am comfortable in once again! That feels so good. I am continuing to eat clean and exercise, it is a great life change!

JG—Vienna, VA

June4, 2009. “Good morning! I have to tell you that I weigh 157… down from 191!!! OMG…thank you so much! I feel incredible!”

KB – Reston, VA

You are so great! I truly appreciate all you are doing for me. Phyllis and I are so fortunate to have found you.

TB - Pottstown, PA

“So far I have lost 30#’s in 6 weeks and have the energy of a 40 year old. Am so thankful to be able to handle unpacking and shelving 6000 books. I am up and down stepladders and extension ladders with books in tow. The awful arthritis pain is there but the energy isn’t depleted from the pain like before and I keep going like this for hours.”

LL - Winchester, VA

Hi Lynese – In an old file I found a print out from an online longevity calculator I had used in 2007 (www.eons.com). I thought I was doing well because it said I would likely live to 86! But I just re-took the survey. Basically by cutting out the coffee, carbs and sugar, increasing my exercise and losing weight, I’ve apparently added 13 years to my life!! The calculator now says I could live to be 99!! With a little more exercise and a little less work, I could live to 106!! Thanks for all the added years Lynese!!!

All the best.

P.S. – I saw Diane over the weekend – she’s looking great, and is so happy with her weight loss.

AP - Falls Church, VA

Dare I say it out loud? It sure is looking as though Semorelin has given me my life back. I was so worried about skiing – afraid I’d ski one day and be in bed the rest of the week. But I was just fine. This past Saturday I prepared, served, and cleaned up (with help) dinner for 14. Sunday I was just fine.

SJ - McLean, Virginia

Dear Lynese,

Words cannot describe how happy I am with your anti-aging program. I have not felt this good in YEARS. Since getting pregnant in 1995 I have been overweight. Between 1992-1995 I was being treated for infertility and had to take all sorts of hormones that made me bloated and tired.

Now, at the age of 46 I have more energy and I look better than I have in YEARS. I actually THRIVE on exercise and do it religiously because I know it is the key to keeping the weight off and enjoying the foods that I love.

As a successful businesswoman, you often feel that you can’t have everything and I put my weight and health on hold to grow my business. You have given me the gift of being able to run a business AND look good. I am getting so much attention for my weight loss and it has helped my confidence and self esteem greatly.Since I do a lot of speaking engagements, I know that image is more important than what you say or how you say it. By looking better and appearing fit and healthy, I am a more powerful public speaker!

I can’t say enough about this gift you have given me and I hope you know how much I appreciate you.

On top of all of this, you are truly a beautiful person inside and out who provides a level of caring I have never seen from a doctor, weight loss clinic or other health professional.

HAVE A GREAT DAY!!!!!!!!!!!!!!

KB - Reston VA

Hi Lynese – Just had to share this with you. I have appeared in an online newsletter (Legal Bisnow) twice – the first time a year ago and the second time today. Look at the difference in my photos!

It’s an absolute miracle! In the older photo even my eyelids look fat! I can’t get over how much I now look like my old self – of 20 years ago! I certainly don’t look like I’m closing in on 59, do I??

The best thing anyone has said to me so far was a comment made by a neighbor who saw me today for the first time in over a year. At first he didn’t recognize me. Then he just stared intently into my face for a few minutes and said “How is your mother?” (I was confused because he doesn’t know my mother). Then he said “I had to ask that because you look like your own daughter!” Wow!

Thank you, thank you, thank you!!!

AP - Falls Church, VA

“With that said, I have been getting incredible compliments:
“You look like a movie star”
“What have you been doing”
“You look amazing”
“You look ten years younger”
I feel incredible”

KB - Reston, VA

Anyway – just had to tell you that my size 12 pants have been falling off of me! I went to Target this weekend to get some cheap crop pants and shorts for the summer – still not wanting to invest much in clothes that are not my “target” size. (I’ve blown past the size 14 shorts I couldn’t fit into for years). And wouldn’t you know – the 12s were too big – I fit best in the size 10!!

I’M A 10!!! I’m amazed!!

I broke the 170 barrier too – I’m now 168. Just 13 pounds to go to my goal weight. I can’t believe it. The meds have been working like a charm. I think the extra thyroid has really boosted me past a plateau. I’m cleaning out my closet like a madwoman; I can’t believe how much clothing I have for donations.

I’m still getting double takes and amazed looks from people who haven’t seen me for awhile. And after remarking how great I look, a girlfriend recently peered suspiciously at me and said – “And have you had something done to your face too? You look younger!” And I do!

AP - Falls Church, VA 6/2010

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Take our quick assessment. Or, if you are a concerned observer, answer from your observations of their behavior. If you or the observed person have more than 1 of the listed symptoms above, a cognitive evaluation is in order.

Signs and symptoms of AD are not normal signs of aging. If you or someone you love is experiencing any of these symptoms, it is important to make an appointment as possible because AD worsens over time.

AD is a progressive disease and although there is no cure, the Bredesen’s protocol has been able to slow and reverse cognitive decline. Remember, the earlier AD is caught, the easier it is to successfully treat the condition.

Once a person has noticeable symptoms, they are in the later stages of cognitive decline. AD has an initial “silent phase,” where brain degeneration is occurring but these changes are not detectable using objective tests. Patients may, however, notice slight memory and cognitive changes. See the image below.

Understanding AD and dementia and separating them from “general aging”

AD is a form of dementia as illustrated by the graphic below:

For understanding and to separate Alzheimer’s from “normal aging” it is helpful to define AD.   Alzheimer’s disease (AD) is an irreversible (?), progressive brain disorder that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks. It is characterized by the development of amyloid plaques and neurofibrillary, or tau, tangles; the loss of connections between nerve cells (neurons) in the brain; and the death of these nerve cells. It is the most common cause of dementia in older adults. While dementia is more common as people grow older, it is not a normal part of aging.  There are two types of Alzheimer’s—early-onset (very rare) and late-onset. Both types have a genetic component.

  1. Early-onset AZ is caused by any one of a number of different single-gene mutations on chromosomes 21, 14, and 1. Each of these mutations causes abnormal proteins to be formed. Mutations on chromosome 21 cause the formation of abnormal amyloid precursor protein (APP). A mutation on chromosome 14 causes abnormal presenilin 1 to be made, and a mutation on chromosome 1 leads to abnormal presenilin 2.

  Each of these mutations plays a role in the breakdown of APP, a  protein whose precise function is not yet      fully understood. This breakdown is part of a process that generates harmful forms of amyloid plaques, a      hallmark of the disease.

  1. Most people with Alzheimer’s have the late-onset form of the disease, in which symptoms become apparent in the mid-60s and later. The causes of late-onset Alzheimer’s are not yet completely understood, but they likely include a combination of genetic, environmental, and lifestyle factors that affect a person’s risk for developing the disease.

Researchers have not found a specific gene that directly causes the late-onset form of the disease. However, one genetic risk factor—having one form of the apolipoprotein E (APOE) gene on chromosome 19—does increase a person’s risk. APOE comes in several different forms, or alleles:

  • APOE ε2 is relatively rare and may provide some protection against the disease. If Alzheimer’s disease occurs in a person with this allele, it usually develops later in life than it would in someone with the APOE ε4 gene.
  • APOE ε3, the most common allele, is believed to play a neutral role in the disease—neither decreasing nor increasing risk.
  • APOE ε4 increases risk for Alzheimer’s disease and is also associated with an earlier age of disease onset. A person has zero, one, or two APOE ε4 alleles. Having more APOE ε4 alleles increases the risk of developing Alzheimer’s.
    • APOE ε4 is called a risk-factor gene because it increases a person’s risk of developing the disease. However, inheriting an APOE ε4 allele does not mean that a person will definitely develop Alzheimer’s. Some people with an APOE ε4 allele never get the disease, and others who develop Alzheimer’s do not have any APOE ε4 alleles.

Understanding APOE and its role in development of AD

Apolipoprotein E (apoE) has multiple roles, including lipid transport in the blood and the brain. The APOE4 variant increases the risk for late-onset Alzheimer’s disease and may contribute to the pathology of the disease through influence on β-amyloid, inflammation, or other processes.

The risk for development of late-onset AD is increased approximately two- to threefold for individuals with one copy of the APOE4 variant and by approximately 10- to 15-fold for individuals with two copies of the variant (E4/E4 genotype). The APOE2 variant has some protective effect against development of late-onset AD. The lifetime risk for late-onset Alzheimer’s disease is approximately 10% to 12% in the general population, though it is higher in women than men and doubles when there is a first-degree relative with this disorder. The lifetime risk is approximately 9% for individuals negative for APOE4, and for individuals with E4/E4 may be as high as 25% for males and 45% for females. Among patients with late-onset AD, the presence of APOE4 may lead to earlier development of symptoms.

What can a person do to minimize their risk for developing AZ?

Given that science has not yet established a specific causal factor, it is believed that the development of the disease is based on a combination of genetics (APOE), lifestyle factors, history of head trauma (ex. Athletes like football players), mitochondrial damage and toxin exposure including biotoxins (Mold exposure).  From our functional medicine underpinning, we know that mitochondrial damage can be initiated by free radical damage and that this can be mitigated through effective detoxification, proper nutritional supplementation, ensuring gut health, healthy eating and other lifestyle factors. From our knowledge about the damage inflicted by CIRS (Chronic Inflammatory Response Syndrome from mold exposure) it is easy to conceptualize how CIRS is related to cognitive decline as may CIRS patients experience reversible cognitive decline if CIRS is left untreated.

After much research, Dr. Lawson determined that the Bredesen protocol provides the best evidenced-based approach to diagnosing and treating cognitive decline from AD and related illnesses.  The world renowned Dr. Dale Bredesen has created the ReCODE protocol that involves multiple strategies to address specific health issues that contribute to Alzheimer’s Disease (AD). The results of each strategy are measured by using blood tests, cognitive evaluations, and other markers of overall health improvements.  Dr. Lawson is now Bredesen Certified as she has completed the study and certification requirements to be able to offer patients the full ReCODE protocol to help them recover from these debilitating illnesses.

At the forefront of this functional medicine approach to AD is Dr. Dale Bredesen and his team from the Buck Institute for Research on Aging. Through careful examination of the pathogenesis of Alzheimer’s, Dr. Bredesen and his team have found promising results. They have developed a multiple modality approach to achieving what they call metabolic enhancement for neurodegeneration (MEND), now referred to as Reversal of Cognitive Decline or ReCODE.

Through the approach Dr. Bredesen has developed, patients have been able to dramatically improve cognitive function, achieve reversal of symptoms, and in some cases, return to work. The ReCODE program includes lifestyle interventions, therapeutic diets, and targeted nutrients.  We are excited to add this promising modality for the benefit of patients of Proactive Wellness Centers.

In short, our Brain Health Optimization (BHO) Evaluation and Treatment program includes the following elements:

Part 1: 2 hour in-office consultation to review core test results.

Part 2: Physical Examination (usually on same day as Part 1)

Part 3: Baseline Cognitive Assessment (typically on same day as Part 1)

Part 4: 1.5 hour additional consultation (Day 2 or later depending on availability of test results).  This appointment can be in office or it can be a tele-video visit to cover the remaining tests that were not covered in the initial visit and review the core elements of a personalized treatment plan.  In this visit, we will present the results of our evaluation in a personalized “cognoscopy”.  We are sure that it will be enlightening.

Below is a detailed listing of the tests that are potentially included in the Comprehensive Brain Health Assessment.

  1. Comprehensive Initial Brain Health Assessment ($3475.00) Includes the following.
    1. Baseline labs and physical examination. A very complete set of baseline labs that will evaluate the entire spectrum of health and a baseline physical examination closely following the Bredesen protocol.  This goes well beyond standard labs to include magnesium, zine and selenium levels, B6, B12 and folate levels, Omega 3 and omega 6 fatty acid levels, pre-diabetes evaluation, hormone levels, thyroid levels as well as specific immune markers like TH1, TH2, IL6 and TNF.
    2. A baseline Cognitive Assessment. This is to establish a baseline and evaluate you against an age-specific norm to determine the state of your cognitive function today. We are using the CNS Vital Signs cognitive assessment, one of the most highly regarded assessments in the industry.
    3. Apolipoprotein E (APOE) genetic test. We are aware that most patients have insurance but the problem is that most insurance companies are not covering genetic tests.  And to help avoid patients getting an unexpectedly large bill, we are including this test in our program fee.
    4. Biotoxin illness Assessment. As there is emerging data to show that the presence of biotoxin illnesses greatly enhances a patient’s risk for developing AZ, this has to be a part of our brain health assessment.  If indicated by a screening questionnaire, the panel leverages the most critical markers from the published literature for determining if a patient’s health is being impacted by CIRS including TGB-Beta 1, MSH, MMP9, HLA DRB1, 3,5, HLA DQB1, ADH/OS and several others.
    5. Comprehensive infection Assessment.  If indicated by a screening questionnaire, the area of assessment and possible testing looks for borrelia, most Lyme coinfections including babesia, bartonella, ehrlichia, Anaplasma phagocytophilum, Chlamydophila pneumoniae and Rocky Mountain Spotted PCR Fever
    6. Chemical  and heavy metals Immune Reactivity Screen. This area of testing looks for chronic and acute reactivity and antibodies across multiple chemicals and metals including aflatoxins, formaldehyde,   bisphenol A, tetrachloroethylene, parabens, mercury, nickel, cobalt, cadmium, lead, arsenic
    7. Urine mycotoxin testing.  Looks for presence of key mycotoxins in the urine. Mycotoxins are typically produced by mold exposure but there are other producers of mycotoxins as well.
    8. Microbiome testing.  The gut microbiome resides in your large intestine and is host to more than 1000 species of bacteria that perform certain important functions from shaping the immune system to influencing metabolism of nutrients to fortifying the intestinal mucosal barrier.  Microbiome testing helps to identify imbalances in the gut microbiome that may be causing gastrointestinal symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders
    9. Blood brain barrier testing.  This test is used to evaluate breaches of the Blood-Brain Barrier by stress, trauma or environmental triggers
    10. Inflammation/Immune/Auto-Immune Specialty Genetic Panel.  This panel includes 30 gene variants that can affect one’s ability to control/ “turn off” inflammation. Chronic inflammation and oxidative stress can cause premature aging and most chronic diseases, including cancer and is a significant contributor to AD. Understanding a person’s genetic is valuable in both prevention and treatment.
    11. MRI with Neuroquant (NQ).  Listed here for completeness. Not included in the price as this test is covered by most insurances.  Used to assess the brain for structural issues and the NQ is used to determine if atrophy or hypertrophy has occurred in the various brain sectors.  This is useful for assessing biotoxin illness as well as for broader use in AZ risk.
    12. Your own personalized “Cognoscopy”.  The Cognoscopy is a summary report that brings together our findings from all of the testing mentioned above and summarizes your risks as it relates to each of the six Alzheimer’s types, and a summary clinical plan to optimize health and reverse mild cognitive decline if it has begun.    Note that to get the actual prescriptions and clinical plan fine details, you must enroll in the Brain Health Optimization Program outlined below.
  2. Brain Health Optimization Program (BHOP) ($2975 – $9975 for 12 months depending on patient case specifics and scope of our services). Note, price does not include any medications or supplements except as indicated below.  Further, note that all patients who enroll in our Brain Health Optimization Program must commit to a one-year “REVERSE” subscription at $75 per month with Dr. Bredesen at https://apollo.ahnphealth.com/logins/new
    1. Specific and individually tailored lifestyle modification guidance. Through this program component, we will provide specific and tailored guidance to apply all of the lifestyle modifications that we are currently aware of that help to mitigate risk for developing AD. Naturally, this area will continue to emerge so it will be very dynamic as more emerging credible data is published.
    2. Bioidentical Hormone Replacement as indicated by test results
    3. Treatment for biotoxin and other chronic illnesses as indicated by test results
    4. Development and adjustment as needed of a comprehensive clinical plan for the patient that is driven by the ReCode recommendations
    5. Specific recommended nutritional supplements to enhance brain health. Currently there are two specific supplements that we are using that are supported by solid science and the patient will be supplied with these for the duration of the program. The two supplements are listed below and the price includes a supply of these nutrients for the duration of the program:
      1. Microdose Lithium. Lithium has been shown to inhibit the destructive GSK-3 enzyme.  GSK-3 is implicated in the chemical changes that destroy brain cells and impair memory. In very high doses, lithium is used for other purposes but the micro-dose lithium has been validated for its GSK-3 inhibiting impact and therefore favorable impact on brain health and avoiding AZ.
      2. Microdose Proline Rich Polypeptides (PRPS) a/k/a Colostrinin, a component of colostrum. Research shows it improves the mental functioning of Alzheimer’s patients. Researchers at the University Medical School in Wroclaw, Poland, conducted a double-blind, placebo-controlled study showing that oral administration of colostrinin, a proline-rich polypeptide (PRP) complex isolated from colostrum, improves the outcome of AD patients with mild to moderate dementia’ Additionally, colostrinin was found to be a remarkably safe natural supplement.
    6. Followup Cognitive Assessments 6 months after program commencement and 11 months. We will compare the results of this assessment with the baseline to determine improvement and/or degradation in cognitive function.

Already have labs and your Recode report and just need a physician to review your Recode report and advise of recommended next steps?  For this, our Bredesen Recode Report Consultation is the place to start.  The fee for this is $975.00 and includes a 2 hour physician review and consultation preceded by a cognitive evaluation and physical examination.

We are truly excited to bring this program forth to our patient population. Dr. Lawson is passionate about this area of our health and she is committed to being on the leading-edge or the emerging treatment protocols.  Ready to get started?  Use one of the options below.

  1. Click here to contact us on our quick contact form and someone will get back with you shortly.
  2. If between the hours of 9:00 AM – 5:00 PM Monday through Friday, feel free to call us now on (703) 822-5003 and our Clinical Intake Coordinator will answer any question you have and get you started.
  3. If you know this is the program for you, then Click here to begin the online enrollment process

Not ready to start for sure, but just want to get a 30 minute age-normalized cognitive assessment  and MoCA evaluation with 15 minute clinical review for $375, then  Click here to learn more about our quick but comprehensive neurocognitive assessment.

Helpful Resources for Alzheimer’s disease and the Bredesen Protocol

Here is the proof that the Bredesen Protocol really works. Over 100 patients, multiple practitioners, multiple geographies, results sustained over time.  Click here  to read the details:

Check out this report that concludes why existing drugs and drugs that once showed promise in early clinical trials have failed.  Bottom line, Dr. Bredesen and the ReCode protocol has the answers.  Traditional therapies are stuck looking for the “magic bullet”.  Click here to read more…