Personalized Precision Medicine with advanced Nutrigenomics featuring Gx Sciences

Through our work in treating chronic disease over the past 5 years, we have learned that genetics play a major role in how both foods, medications and supplements are metabolized and used by the body and accordingly a person’s genetics may cause a therapy that is the right therapy for many but it may be the wrong therapy for you.

Why is it important to understand our genetics?

Here are some facts that led us to proceed aggressively to begin using nutrigenomic testing and personalized interventions to help our patients, and why you should consider Proactive Wellness your partner in understanding how your genetics are keeping you from being your best or even worse, contributing to your present illness.

  • Genetic variants are more common than we have thought
  • Specifically, more than 75% of all patients have significant genetic weaknesses (SNPs) in the most important nutritional metabolism pathways.
  • With genetic variants in key metabolism pathways, food, supplements and medications are not metabolized in the expected way, leading to imbalances that potentially have an adverse impact on health.

Examples of genetic weaknesses

For example, if a patient has genetic weaknesses in the immune system “off switches” like SNP CTLA4, they will not be able to effectively turn off inflammatory cytokines, leading to run away inflammation.  With a weakness in CTLA4, a patient that experiences an inflammation triggering event (stress, vaccines, infections, environmental toxins, etc.) may experience a dramatic increase in inflammatory cytokines, but with the weakness in CTLA4, they cannot effectively modulate or “turn off” the inflammation.  Another example is the dreaded C677T, a variant in the Methylation process (MTHFR) whereby a person’s methylation capability is degraded by 40%/70% (hetero/homo).  The methylation process produces methylfolate, which is central to generating energy and ATP and is used to make three key neurotransmitters dopamine, serotonin and GABA. With degraded capability to make methylfolate, patients typically suffer low energy, fatigue and numerous other symptoms due to the reduced production of dopamine, serotonin and GABA, three very key neurotransmitters.  This is why the MTHFR mutation is one of the most studied and reported on variants as it alone has a very strong impact on quality of life.  At Proactive Wellness, we know the ins and outs of treating patients with the MTHFR variants and helping them to optimize their health while concurrently dealing with other health issues.

What is nutrigenomics?

The scientific study of individualized genetics and nutrition is known as nutritional genomics or “nutrigenomics”. Nutrigenomic testing accurately identifies each patients’ genetic protein variations to identify sites of metabolic weakness. These key proteins are involved in enzyme conversion, nutritional delivery and signaling pathways in the cell. Single nucleotide polymorphisms (SNPs) can affect a patient’s ability to regain and maintain their metabolic functionality. Abnormalities in specific SNPs can negatively affect many physiological and metabolic processes. Overcoming these metabolic weaknesses with the right supplement allows each patient to overcome their genetic weaknesses (SNPs) and maintain optimal health.

Keep in mind that just because a patient has a genetic variant (weakness), it does not mean they have or will have a disease. It just means they have a predisposition for a condition due to degraded capability, if exposed to the right environment, the defective gene may be responsible for the patient becoming ill. A Genomic SNP is like a crack in the foundation of a bridge.  With nutrigenomic testing, we are able to identify the cracks in the foundation before they present as disease. Then with personalized, precision medicine, we can help patients avoid disease.

We have partnered with GX Sciences as our nutrigenomics provider because GX is backed by far by the most science and their approach allows us to more specifically target the SNPs that are having the most impact on the health of the patient.  Importantly, the Chief Medical Science Officer for GX is the world renowned Kendal Stewart, MD.  He is a board-certified Otolaryngology/Head and Neck Surgery specialist, Neurotologist and Neuro-immune specialist. He has done pioneering research in the field of nutrigenomics and has led Gx to a leadership position in the space.   Specifically, GX helps us to:

  • Determine each patient’s unique genetic-based metabolic weaknesses
  • Determine which of the SNPs are material and therefore need to be supported
  • Provide a science-based algorithm that guides the practitioner to the targeted interventions and supplements and the proper timing of delivery

Further, Gx is using the latest research.  Consider that the research supporting the role of CTLA4 as a braking mechanism on other T- Cells just won the Nobel Prize in Physiology or Medicine in 2018. Here is a link to the article: https://www.nobelprize.org/prizes/medicine/2018/press-release/

Clearly, GxSciences is on the leading-edge of medicine and we are pleased to partner with them.

What is Personalized Precision Medicine?

Personalized, Precision Medicine is treatment that we deliver by providing the right medication, targeted nutraceuticals and dietary guidance at the right time, in the right amounts based on your genetic profile, laboratory results and symptomatic expression.  Consider that if a patient has a methylation deficiency and significant inflammation, adding methylfolate (which is the right ingredient) without first addressing inflammation (wrong time) will almost always make them sicker. It is like baking a cake that has a specific order of ingredients and all you know is the ingredients without the order.  Without the proper order, you don’t the intended result.

Personalized Precision Medicine doesn’t stop with understanding genetic weaknesses/SNPs and treating patients to help them avoid disease or recover from disease, but we can also use your genetics to help you get the optimal benefit from needed medications and avoid many adverse impacts.  The field of science that studies drug to human interactions based on the human genome is called Pharmaco Genomic testing, otherwise known as PGx. This refers to a type of genetic test to predict a patient’s likelihood to experience an adverse event or not respond to a given drug. Genetic variation in metabolism may result in high concentrations of drugs and an increased risk of adverse effects in slow metabolizers, which is important when using, for example, antidepressants or pain medication.  Just as there are known drug-drug interactions, there are also known drug-gene interactions. Pharmacogenomics is the study of how a person’s genes affect their response to specific medications.

With our partner GxSciences, we can provide you with a PGx report that we will certainly use if we find it necessary to recommend any medications but you can also share this with you PCP and other providers to help them make the best decisions for your health as well. It will help not only with determine the right medication, but also with dosing since if by genetics you are a fast metabolizer or a slow metabolizer, this has significant impact on dosing.

How do I get started with Personalized Precision Medicine with Proactive Wellness Centers?

There are several starting points to working with PWC in get your own clinical plan that is driven by our our Personalized Precision Medicine approach, depending on whether you are presenting with disease already or presenting as a well patient trying to avoid disease.  Read on below to understand some of our starting points.

Comprehensive Initial Assessment with Foundation Genetics $900 (includes the genetic test)

This is our Comprehensive Initial Assessment (CIA) with foundation genetics.  For the CIA, patients register inclusive of filling detailed health information, then we follow that with a lab order for standard and advanced disease markers and we will send you the genetic kit for you to swab and submit directly to the lab.  Foundation genetics is for our well patients seeking to optimize, and it includes 22 SNPs that cover methylation (MTHFR and related variants), vitamin d transport, detoxification weakness, mitochondrial weakness and some immune SNPs.  When the results are back, you will meet with the our Medical Director for 2 hours to review your lab and genetic results, discuss your diagnosis and treatment plan.

Note that that pricing for this option assumes that you have insurance to cover the standard blood labs.

Foundation Genetics Only $425 with 30-minute visit to review genetic report only

This option is for patients that just want the nutrigenomics report only along with a 30-minute visit to review the result.  This option includes genetic recommendations but will not include a detailed treatment plan discussion since we will not have labs to provide the necessary context.

Pharmacogenomic Testing Only $450 with 30-minute visit to review report only

This option is for patients that want the pharmacogenetics report only along with a 30-miute visit to review the results.  This option does not include a detailed treatment plan discussion.

PATIENT RESPONSE

You are so great! I truly appreciate all you are doing for me. Phyllis and I are so fortunate to have found you.

TB - Pottstown, PA

June4, 2009. “Good morning! I have to tell you that I weigh 157… down from 191!!! OMG…thank you so much! I feel incredible!”

KB – Reston, VA

“So far I have lost 30#’s in 6 weeks and have the energy of a 40 year old. Am so thankful to be able to handle unpacking and shelving 6000 books. I am up and down stepladders and extension ladders with books in tow. The awful arthritis pain is there but the energy isn’t depleted from the pain like before and I keep going like this for hours.”

LL - Winchester, VA

Dare I say it out loud? It sure is looking as though Semorelin has given me my life back. I was so worried about skiing – afraid I’d ski one day and be in bed the rest of the week. But I was just fine. This past Saturday I prepared, served, and cleaned up (with help) dinner for 14. Sunday I was just fine.

SJ - McLean, Virginia

My update. I feel pretty good!!! My bleeding is under control and I am now regular for the most part. Sometimes I will have a strange menstral bleed (long and slow), but I will take it compared to my old “normal”. I still love the progesterone and testosterone I am on. They leave me with no side effects.

I was very happy at my recent (Feb 6th) annual doc appt (physical). After the standard blood draw work up, my numbers were:
Vitamin D= 66.9 (down a bit from your work up which was 77, but still good)
Cholesterol=123 (down from 150 in Sept 2011)
Triglycerides=91 (down from 129 in Sept 2011)

So… I am the new spokesperson for HCG! I love that stuff!! smile The second round for me was amazing. I was very disciplined and determined and after about the 3rd day, it become very easy for me. I was able to drop 14lbs in an 18 day cycle!!!! AND….I am keeping that off with very little effort! OMG I couldn’t be happier! I am in the body that I am comfortable in once again! That feels so good. I am continuing to eat clean and exercise, it is a great life change!

JG—Vienna, VA

Dear Lynese,

Words cannot describe how happy I am with your anti-aging program. I have not felt this good in YEARS. Since getting pregnant in 1995 I have been overweight. Between 1992-1995 I was being treated for infertility and had to take all sorts of hormones that made me bloated and tired.

Now, at the age of 46 I have more energy and I look better than I have in YEARS. I actually THRIVE on exercise and do it religiously because I know it is the key to keeping the weight off and enjoying the foods that I love.

As a successful businesswoman, you often feel that you can’t have everything and I put my weight and health on hold to grow my business. You have given me the gift of being able to run a business AND look good. I am getting so much attention for my weight loss and it has helped my confidence and self esteem greatly.Since I do a lot of speaking engagements, I know that image is more important than what you say or how you say it. By looking better and appearing fit and healthy, I am a more powerful public speaker!

I can’t say enough about this gift you have given me and I hope you know how much I appreciate you.

On top of all of this, you are truly a beautiful person inside and out who provides a level of caring I have never seen from a doctor, weight loss clinic or other health professional.

HAVE A GREAT DAY!!!!!!!!!!!!!!

KB - Reston VA

Hi Lynese – In an old file I found a print out from an online longevity calculator I had used in 2007 (www.eons.com). I thought I was doing well because it said I would likely live to 86! But I just re-took the survey. Basically by cutting out the coffee, carbs and sugar, increasing my exercise and losing weight, I’ve apparently added 13 years to my life!! The calculator now says I could live to be 99!! With a little more exercise and a little less work, I could live to 106!! Thanks for all the added years Lynese!!!

All the best.

P.S. – I saw Diane over the weekend – she’s looking great, and is so happy with her weight loss.

AP - Falls Church, VA

Hi Lynese – Just had to share this with you. I have appeared in an online newsletter (Legal Bisnow) twice – the first time a year ago and the second time today. Look at the difference in my photos!

It’s an absolute miracle! In the older photo even my eyelids look fat! I can’t get over how much I now look like my old self – of 20 years ago! I certainly don’t look like I’m closing in on 59, do I??

The best thing anyone has said to me so far was a comment made by a neighbor who saw me today for the first time in over a year. At first he didn’t recognize me. Then he just stared intently into my face for a few minutes and said “How is your mother?” (I was confused because he doesn’t know my mother). Then he said “I had to ask that because you look like your own daughter!” Wow!

Thank you, thank you, thank you!!!

AP - Falls Church, VA

“With that said, I have been getting incredible compliments:
“You look like a movie star”
“What have you been doing”
“You look amazing”
“You look ten years younger”
I feel incredible”

KB - Reston, VA

Hi – hope you are doing well. Are you ready for Thanksgiving? I’m getting there. I wanted to let you know I hit the 30 lb loss today!!! Yeah! So excited! Clothes that didn’t fit are fitting. Clothes I used to wear are too big. Feeling great! A little nervous about tomorrow’s feeding frenzy- but hoping to not overindulge too bad.

LJ - Arlington, VA

Anyway – just had to tell you that my size 12 pants have been falling off of me! I went to Target this weekend to get some cheap crop pants and shorts for the summer – still not wanting to invest much in clothes that are not my “target” size. (I’ve blown past the size 14 shorts I couldn’t fit into for years). And wouldn’t you know – the 12s were too big – I fit best in the size 10!!

I’M A 10!!! I’m amazed!!

I broke the 170 barrier too – I’m now 168. Just 13 pounds to go to my goal weight. I can’t believe it. The meds have been working like a charm. I think the extra thyroid has really boosted me past a plateau. I’m cleaning out my closet like a madwoman; I can’t believe how much clothing I have for donations.

I’m still getting double takes and amazed looks from people who haven’t seen me for awhile. And after remarking how great I look, a girlfriend recently peered suspiciously at me and said – “And have you had something done to your face too? You look younger!” And I do!

AP - Falls Church, VA 6/2010

Hi Lynese — Great news – seems a fibroid has disappeared! The ultrasound revealed only one fibroid this time, and it is just a little teensy bit smaller than before. So it hasn’t gotten any bigger at all. And the other fibroid didn’t show up on the ultrasound. smile

Thank goodness I did not get that hysterectomy, huh? and thank goodness I came to you to start the bio-identical hormone therapy. I believe that the progesterone is working. And I’m so glad I’m not on the birth control pills anymore. BTW, haven’t had a period since September, and haven’t had any hot flashes either! Life is good.

AK - Germantown, MD

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