Intestinal Permeability aka “Leaky Gut” Diagnosis and Treatment

Leaky gut syndrome Treatment doesn’t happen overnight, but over time due to eating foods we are sensitive to, poor diet in general, gluten and numerous other factors, patients end up with abnormally large spaces in between the cells of the gut wall.

Leaky gut Syndrome. difference between Healthy cells, and inflamed intestinal cells. Comparison normal tissue of the gastrointestinal tract, and leaky gut.

These large spaces allow all sorts of toxic materials through and can cause a runaway reaction of inflammation and increased permeability.  Leaky gut Syndrome is a major issue and is associated with a number of auto-immune conditions and is involved in literally every patient with chronic illness like Lyme, Mold/CIRS and neurodegenerative diseases like Alzheimer’s and Dementia.

Causes of Leaky Gut

The list of root causes is long and includes:

  • Medications (NSAIDS) like ibuprofen and motrin
  • Microbial overgrowth or infection
  • Parasite infections
  • Fungal overgrowth (Candida)
  • Ingestion of allergenic foods or foods the patient is sensitive to
  • Maldigestion/malabsorption (pancreatic insufficiency or low HCl)
  • Radiation therapy or chemotherapy
  • Stress
  • Aging
  • IgA deficiency
  • Chronic alcohol intake
  • Excessive or strenuous exercise
  • Inflammatory bowel disease – Crohn’s or Ulcerative colitis

Symptoms of Leaky Gut

Gas, bloating, diarrhea, constipation or generalized abdominal discomfort are some of the key symptoms.  But leaky gut may also cause allergies and sensitivities that a patient hasn’t had all along as well as lack of energy and fatigue.  Hint — patients with more than a handful of severe and moderate food sensitivities almost always have leaky gut.  

Diagnosis of leaky gut

The diagnosis of leaky gut is based on a combination of symptomatic expression and the results of specialized laboratory tests.  Generally if a patient has more than a handful of severe sensitivities on any of the high-quality food sensitivity test panels, this is a good indication of leaky gut.  Accordingly, food sensitivity testing is one of the diagnostic tools used for leaky gut diagnosis.  Positive indicators for leaky gut include anti-zonulin antibodies, lipopolysaccharides (LPS) and anti-actin antibodies.  These are direct indicators of leaky gut and can be found on many of the specialized tests for gut issues.

Treatment of leaky gut

Our comprehensive functional medicine treatment plan consists of 3 steps.  Expect treatment to take from 3 months for mild cases to 6-9 months for severe cases.  The steps are as follows:

  1. Preparing and Eliminating. This step consists of preparing the body in part by eliminating the foods identified in the food sensitivity test to be severe or moderate.  Additionally, patients should eliminate NSAID-class medications if at all possible even if it means switching to a non-NSAID type anti-inflammatory medication.  Reducing or eliminating alcohol and eliminating strenuous exercise are the final components to the preparing and eliminating step.
  2. Implement the PWC Nutraceutical Leaky Gut Protocol.  The components are listed below.
    • Full spectrum Binder.  We generally use Biotic Reserch GI Detox or Cell Core Biosciences Carboxy.   Reducing toxins helps the facilitates gut healing.
    • Probiotics. Probiotics are key to restoring gut health.  We generally use Multibiome by Xymogen.
    • Digestive Enzymes. Digestive enzymes help a damaged gut fully digest foods, which reduces the amount of partially digested, toxic particles that are impacting the intestinal lining so these are a needed step in healing.
    • Glutamine. Glutamine is an amino acid that has been shown to be effective in healing leaky gut
    • Quercetin. Stabilizes mast cells, reduces inflammation, helps seal the leakiness.
  3. Evaluate and retest.  This final test consists of evaluating the patient for symptom elimination and retesting when healing appears to be complete.  Healing will take between 3-9 months depending on severity of the condition and patient response.

Think you can go it alone and treat yourself?  In most cases, patients are not successful with self treatment because they don’t know how/when to add the right ingredients, how to titrate for variations in patient response and how to otherwise overcome the individuality that exists with each patient.

Ready to get PWC engaged to end your leaky gut? Fill the contact form below and we will get back to you within 24 hours except weekends.

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You are so great! I truly appreciate all you are doing for me. Phyllis and I are so fortunate to have found you.

TB - Pottstown, PA

June4, 2009. “Good morning! I have to tell you that I weigh 157… down from 191!!! OMG…thank you so much! I feel incredible!”

KB – Reston, VA

“So far I have lost 30#’s in 6 weeks and have the energy of a 40 year old. Am so thankful to be able to handle unpacking and shelving 6000 books. I am up and down stepladders and extension ladders with books in tow. The awful arthritis pain is there but the energy isn’t depleted from the pain like before and I keep going like this for hours.”

LL - Winchester, VA

Dare I say it out loud? It sure is looking as though Semorelin has given me my life back. I was so worried about skiing – afraid I’d ski one day and be in bed the rest of the week. But I was just fine. This past Saturday I prepared, served, and cleaned up (with help) dinner for 14. Sunday I was just fine.

SJ - McLean, Virginia

My update. I feel pretty good!!! My bleeding is under control and I am now regular for the most part. Sometimes I will have a strange menstral bleed (long and slow), but I will take it compared to my old “normal”. I still love the progesterone and testosterone I am on. They leave me with no side effects.

I was very happy at my recent (Feb 6th) annual doc appt (physical). After the standard blood draw work up, my numbers were:
Vitamin D= 66.9 (down a bit from your work up which was 77, but still good)
Cholesterol=123 (down from 150 in Sept 2011)
Triglycerides=91 (down from 129 in Sept 2011)

So… I am the new spokesperson for HCG! I love that stuff!! smile The second round for me was amazing. I was very disciplined and determined and after about the 3rd day, it become very easy for me. I was able to drop 14lbs in an 18 day cycle!!!! AND….I am keeping that off with very little effort! OMG I couldn’t be happier! I am in the body that I am comfortable in once again! That feels so good. I am continuing to eat clean and exercise, it is a great life change!

JG—Vienna, VA

Dear Lynese,

Words cannot describe how happy I am with your anti-aging program. I have not felt this good in YEARS. Since getting pregnant in 1995 I have been overweight. Between 1992-1995 I was being treated for infertility and had to take all sorts of hormones that made me bloated and tired.

Now, at the age of 46 I have more energy and I look better than I have in YEARS. I actually THRIVE on exercise and do it religiously because I know it is the key to keeping the weight off and enjoying the foods that I love.

As a successful businesswoman, you often feel that you can’t have everything and I put my weight and health on hold to grow my business. You have given me the gift of being able to run a business AND look good. I am getting so much attention for my weight loss and it has helped my confidence and self esteem greatly.Since I do a lot of speaking engagements, I know that image is more important than what you say or how you say it. By looking better and appearing fit and healthy, I am a more powerful public speaker!

I can’t say enough about this gift you have given me and I hope you know how much I appreciate you.

On top of all of this, you are truly a beautiful person inside and out who provides a level of caring I have never seen from a doctor, weight loss clinic or other health professional.

HAVE A GREAT DAY!!!!!!!!!!!!!!

KB - Reston VA

Hi Lynese – In an old file I found a print out from an online longevity calculator I had used in 2007 ( I thought I was doing well because it said I would likely live to 86! But I just re-took the survey. Basically by cutting out the coffee, carbs and sugar, increasing my exercise and losing weight, I’ve apparently added 13 years to my life!! The calculator now says I could live to be 99!! With a little more exercise and a little less work, I could live to 106!! Thanks for all the added years Lynese!!!

All the best.

P.S. – I saw Diane over the weekend – she’s looking great, and is so happy with her weight loss.

AP - Falls Church, VA

Hi Lynese – Just had to share this with you. I have appeared in an online newsletter (Legal Bisnow) twice – the first time a year ago and the second time today. Look at the difference in my photos!

It’s an absolute miracle! In the older photo even my eyelids look fat! I can’t get over how much I now look like my old self – of 20 years ago! I certainly don’t look like I’m closing in on 59, do I??

The best thing anyone has said to me so far was a comment made by a neighbor who saw me today for the first time in over a year. At first he didn’t recognize me. Then he just stared intently into my face for a few minutes and said “How is your mother?” (I was confused because he doesn’t know my mother). Then he said “I had to ask that because you look like your own daughter!” Wow!

Thank you, thank you, thank you!!!

AP - Falls Church, VA

“With that said, I have been getting incredible compliments:
“You look like a movie star”
“What have you been doing”
“You look amazing”
“You look ten years younger”
I feel incredible”

KB - Reston, VA

Hi – hope you are doing well. Are you ready for Thanksgiving? I’m getting there. I wanted to let you know I hit the 30 lb loss today!!! Yeah! So excited! Clothes that didn’t fit are fitting. Clothes I used to wear are too big. Feeling great! A little nervous about tomorrow’s feeding frenzy- but hoping to not overindulge too bad.

LJ - Arlington, VA

Anyway – just had to tell you that my size 12 pants have been falling off of me! I went to Target this weekend to get some cheap crop pants and shorts for the summer – still not wanting to invest much in clothes that are not my “target” size. (I’ve blown past the size 14 shorts I couldn’t fit into for years). And wouldn’t you know – the 12s were too big – I fit best in the size 10!!

I’M A 10!!! I’m amazed!!

I broke the 170 barrier too – I’m now 168. Just 13 pounds to go to my goal weight. I can’t believe it. The meds have been working like a charm. I think the extra thyroid has really boosted me past a plateau. I’m cleaning out my closet like a madwoman; I can’t believe how much clothing I have for donations.

I’m still getting double takes and amazed looks from people who haven’t seen me for awhile. And after remarking how great I look, a girlfriend recently peered suspiciously at me and said – “And have you had something done to your face too? You look younger!” And I do!

AP - Falls Church, VA 6/2010

Hi Lynese — Great news – seems a fibroid has disappeared! The ultrasound revealed only one fibroid this time, and it is just a little teensy bit smaller than before. So it hasn’t gotten any bigger at all. And the other fibroid didn’t show up on the ultrasound. smile

Thank goodness I did not get that hysterectomy, huh? and thank goodness I came to you to start the bio-identical hormone therapy. I believe that the progesterone is working. And I’m so glad I’m not on the birth control pills anymore. BTW, haven’t had a period since September, and haven’t had any hot flashes either! Life is good.

AK - Germantown, MD

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