The area of genomics is an emerging area that represents the ultimate in diagnosing CIRS and validating the success of the treatment. Genomic testing allows us to look at gene expression, which is the most reliable and promising way to look at DNA as it shows us patterns of gene expression and changes in gene regulation that can create illness. CIRS and other Illnesses are caused by the “lack of regulation” of regulation. By “lack of regulation”, we mean the body’s mechanisms that are designed to regulate and balance all of the inflammatory and regulatory processes fail and we get the cytokine storm and other effets of dysregulation that is charateristic of CIRS and other auto-immune diseases.
Assessing DNA transcriptomics give us a phenomenal amount of information about the state of the disease, risk factors for acquiring CIRS as well as other illnesses and can illustrate treatment success. The genomics testing is relatively expensive and totally out of pocket so it will not be a fit for all patients, but when economically feasible, the genomics testing is invaluable. The below images illustrate the power of genomic testing by showing gene expression and mitochondrial proteins before and after treatment for CIRS. Note that these are actual images from a real patient’s genomics test that had a confirmed case of CIRS before and after treatment for CIRS. We owe thanks to Dr. Ritchie Shoemaker and Dr. James Ryan for their combined work in this work in this area. The illustrations below are from their work enabled by Dr. Ryan’s discovery of the role of hypometabolism in CIRS was a hallmark finding that underlies other chronic, fatiguing illnesses including CFS, fibromyalgia, and post-Lyme syndrome.